The capture of CO2 from a flue gas stream using chemical absorption was studied using two different aqueous amine solvents: the conventional 30% wt. monoethanolamine (MEA) and the novel 40% wt. piperazine (PZ), using a conventional absorption/stripping flowsheet and different combinations of advanced flowsheet variations including absorber intercooling (AIC), stripper interheating (SIH) and adiabatic lean flashing (ALF), amounting for a total of twelve flowsheet alternatives. Additionally, the conventional flowsheet was also studied using 30% wt. 2-amino 2-methyl 1-propanol (AMP). The simulations were performed in Aspen Plus® v.2006.5 using the latest thermodynamic frameworks published by AspenTech  for each solvent, which include regressed interaction parameters for the ENRTL activity coefficient model, adjusted physical properties and kinetic parameters. The absorption and stripping operations were simulated using the rate-based model built in Aspen Plus®. The conventional MEA flowsheet was found to have a minimum specific reboiler duty around 3.854 GJ/ton CO2 and a minimum total equivalent work around 308 kWh/ton CO2, correspondent to a lean solvent load of 0.24 mol CO2/mol MEA. The limited PZ solubility restricts the correspondent to 0.25 mol CO2/mol PZ, giving a of 3.232 GJ/ton CO2 and a of 286.8 kWh/ton CO2 for the conventional PZ flowsheet. The best technical performance was predicted for the AIC + SIH flowsheet using PZ, obtaining a of 2.463 GJ/ton CO2 and a of 239.5 kWh/ton CO2, representing reductions of 36.1% and 22.4% respectively, when compared to the baseline conventional MEA flowsheet. A simplified economic assessment was performed to account for the different solvents, equipment types and steam quality requirements of the evaluated flowsheets, using the annualised cost of purchased equipment and the utilities cost, obtaining the same preference for the PZ based AIC + SIH flowsheet with 17.7% less cost than the conventional MEA flowsheet.