This research aims to find relationships through a comprehensive set of themes between four art museum spaces designed in four different cities, in four different years, by four different architects. The relationships highlight the complexities of museum architecture, its multiple constituents, and its permanent shaping by the varying cultural conditions of a certain time. This paper uses the four architecture projects not as the ultimate object of analysis; rather they are instruments to exemplify broader topics extracted from the literature review. These are: the relationship of the museum with its urban settings, the interactions between architectural form, artistic practices and exhibition space, and the varying models of visitor experience they each create. In addition to systematically collecting, reading, and analysing books and articles published during the last two decades and the review of current information on the museums’ online sites, this dissertation relies on four case studies: The Museum of Unlimited Growth (1939), The Solomon R. Guggenheim Museum (1959), The Centre Georges Pompidou (1977), and Tate Modern (2000). Although it relies heavily on the literature, it hopes to raise a critical viewpoint and contribute to the efforts towards understanding what shapes the architecture of the museum as well as the thoughtful responsibilities of those involved in this significant scenario; from museum directors, curators, and artists, to architects, policy makers, and visitors.